abstract：BACKGROUND/AIM:Androgen-androgen receptor (AR) signal is known as a powerful driver of prostate cancer progression. We previously reported the limitation of prostate-specific antigen (PSA) at diagnosis as a prognostic biomarker of prostate cancer. Although serum total testosterone (TT) level has been reported as a prog...

journal_title：Anticancer research

authors： Izumi K,Shigehara K,Nohara T,Narimoto K,Kadono Y,Mizokami A

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND/AIM:Salvage androgen-deprivation therapy (ADT) is standard treatment for recurrent prostate cancer after curative therapy. However, the prognostic impact of different treatment modalities on the time to castration resistance remains unclear. In this study, we investigated the prognosis of men treated with sa...

journal_title：Anticancer research

authors： Obata H,Shiota M,Akitake N,Takeuchi A,Kashiwagi E,Dejima T,Kiyoshima K,Inokuchi J,Tatsugami K,Eto M

更新日期：2017-10-01 00:00:00

abstract：:Ovarian clear cell carcinoma represents a distinct histopathological subtype of epithelial ovarian cancer, with poor outcomes, especially in cases diagnosed in advanced stages of disease. However, even in these cases, it seems that the most effective treatment remains debulking surgery to no residual disease. We prese...

journal_title：Anticancer research

authors： Bacalbasa N,Balescu I,Filipescu A

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) directed against epidermal growth factor receptor (EGFR) are important in the treatment of non-small cell lung cancer (NSCLC), especially those harboring EGFR mutations. But little is known regarding the clinical value of serum tumor marker levels measured prior to treatment...

journal_title：Anticancer research

authors： Takeuchi A,Oguri T,Sone K,Ito K,Kitamura Y,Inoue Y,Asano T,Fukuda S,Kanemitsu Y,Takakuwa O,Ohkubo H,Takemura M,Maeno K,Ito Y,Niimi A

更新日期：2017-10-01 00:00:00

abstract：AIM:The aim of the present study was to determine if febuxostat could prevent tumor lysis syndrome (TLS) in children who received induction chemotherapy for hematologic malignancies. PATIENTS AND METHODS:A retrospective analysis was performed in 45 pediatric patients with hematological malignancies who received febuxo...

journal_title：Anticancer research

authors： Kishimoto K,Kobayashi R,Hori D,Sano H,Suzuki D,Kobayashi K

更新日期：2017-10-01 00:00:00

abstract：AIM:The current study aimed to determine the prognostic significance of thrombocytosis in patients with colorectal cancer (CRC) by a meta-analysis of the literature. PATIENTS AND METHODS:The meta-analysis followed the 2009 guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A systematic l...

journal_title：Anticancer research

authors： Gu D,Szallasi A

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND/AIM:Extracts of Paeonia suffruticosa are traditionally used in Chinese medicine to increase blood flow. Recently, this extract has been shown to possess anti-tumor and anti-inflammatory properties, though this mechanism remains unknown. In the current work, we prepared extracts of P. suffruticosa and analyze...

journal_title：Anticancer research

authors： Kim D,Radin D,Leonardi D

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:It is essential that cytotoxic T-lymphocytes (CTLs) recognize tumor-associated antigens (TAAs) and exhibit antitumor effects in immunological responses for tumor rejection. However, only a few cases with oral squamous cell carcinoma (OSCC) have been studied for these antitumor mechanisms. We established a ca...

journal_title：Anticancer research

authors： Okamoto JY,Miyazaki A,Kobayashi JI,Miyamoto S,Sasaki T,Kanaseki T,Hirohashi Y,Torigoe T,Hiratsuka H

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND/AIM:The matrix metalloproteinase (MMP) family of enzymes are in charge of degradation of various components of the extracellular matrix and their functional genetic polymorphisms may be associated with cancer susceptibility. The functional polymorphisms in the promoter region of MMP7 (A-181G and C-153T) have...

journal_title：Anticancer research

authors： Chou AK,Hsiao CL,Shih TC,Wang HC,Tsai CW,Chang WS,Liu LC,Way TD,Chung JG,Bau DT

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:In patients with melanoma, early dissemination via lymphatic and hematogenous routes is frequently seen. Thus, besides clinical follow-up examination and imaging, reliable melanoma-specific serological tumor markers are needed. PATIENTS AND METHODS:We retrospectively compared two serum markers for melanoma,...

journal_title：Anticancer research

authors： Uslu U,Schliep S,Schliep K,Erdmann M,Koch HU,Parsch H,Rosenheinrich S,Anzengruber D,Bosserhoff AK,Schuler G,Schuler-Thurner B

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Inconsistent reporting in published meta-analyses compared to registered protocol are poorly understood. The aim of the study was to assess inconsistencies between registered protocols and published reports among oncology drug meta-analyses. MATERIALS AND METHODS:A cross-sectional study was performed includ...

journal_title：Anticancer research

authors： Delgado AF,Delgado AF

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND/AIM:To develop a scoring system to predict bone metastasis after radical resection within 5 years. PATIENTS AND METHODS:We evaluated the patient records of 1,749 patients, of whom 50 patients developed bone metastasis. Treatment-related factors (age, gender, localization, histology, preoperative carbohydrat...

journal_title：Anticancer research

authors： Li A,Käsmann L,Rades D,Fu C

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND/AIM:Occult cancers' reported rates vary from 2-12% and serous tubal intraepithelial carcinomas (STICs) have been identified in 3-12% of the prophylactically removed tubes of women carrying a BRCA mutation. The aim of this study was to evaluate the incidence of tubal minor epithelial atypia (STIL), STIC, and ...

journal_title：Anticancer research

authors： Ricciardi E,Tomao F,Aletti G,Bazzurini L,Bocciolone L,Boveri S,Landoni F,Lapresa MT,Maruccio M,Parma G,Peccatori F,Petrella MC,Zanagnolo V,Colombo N,Maggioni A

更新日期：2017-09-01 00:00:00

abstract：:Neurotrophins are a family of growth factors that are vital to the proper development of the central nervous system. Their effects on cells are governed by the expression and activation of the tyrosine kinase receptors TrkA, TrkB and TrkC. TrkB has been immensely implicated in mediating neuronal migration, development...

journal_title：Anticancer research

authors： Radin DP,Patel P

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/AIM:We have shown that either chronic nicotine (NIC) exposure or 5-aza-cytidine (AZA) augments oxidative stress-dependent injury through stimulating p66shc in renal cells. Hence, NIC could exacerbate adverse effects of AZA while antioxidants such as resveratrol (RES) could prevent it. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Arany I,Hall S,Faisal A,Dixit M

更新日期：2017-08-01 00:00:00

abstract：AIM:The aim of the study was to evaluate the long-term oncology outcomes of prostate cancer patients receiving robotic-assisted radical prostatectomy (RARP). PATIENTS AND METHODS:We retrospectively evaluated 111 patients with clinically-localized prostate cancer receiving RARP with a mean follow-up of 103.43 months. ...

journal_title：Anticancer research

authors： Hung SC,Yang CK,Cheng CL,Ou YC

更新日期：2017-08-01 00:00:00

abstract：AIM:To investigate the discordance in the programmed cell death-ligand 1 (PD-L1) expression between primary and metastatic tumors and analyze the association between the discordance and the clinical factors in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:Twenty-one NSCLC patients who underwent sur...

journal_title：Anticancer research

authors： Takamori S,Toyokawa G,Okamoto I,Takada K,Kozuma Y,Matsubara T,Haratake N,Akamine T,Katsura M,Mukae N,Shoji F,Okamoto T,Oda Y,Iwaki T,Iihara K,Nakanishi Y,Maehara Y

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/AIM:Bevacizumab (BV) has been used for the treatment of recurrent glioblastoma. However, it also induces epithelial-mesenchymal transition (EMT) in glioblastoma cells, which compromises its efficacy. BATF2 (basic leucine zipper ATF-like transcription factor 2), a multi-target transcriptional repressor, has b...

journal_title：Anticancer research

authors： Huang W,Zhang C,Cui M,Niu J,Ding W

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/AIM:Muscle relaxants, also known as neuromuscular blocking agents, can block nerve impulses to the muscles and are always used in surgery for general anesthesia. However, the effect of muscle-relaxant anesthetics on cell activity in gastric cancer is currently unknown. The present study aimed to examine and ...

journal_title：Anticancer research

authors： Jiang A,Zhao H,Liu X,Yu M,Chen J,Jiang WG

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) have been linked to a number of cancer types including breast cancer. The rate of brain metastases is 10-30% in patients with advanced breast cancer which is associated with poor prognosis. The potential application of miRNAs in the diagnostics and therapeutics of breast cancer with brain ...

journal_title：Anticancer research

authors： Li Z,Peng Z,Gu S,Zheng J,Feng D,Qin Q,He J

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Studies have recommended a 21-gene recurrence score (RS) to optimize adjuvant treatment for patients with early-stage breast cancer (EBC) with hormone receptor-positive (HR+) and human epidermal growth factor receptor-2 negative (HER2-) tumors. This study aimed to prospectively evaluate the impact of this RS...

journal_title：Anticancer research

authors： Zeng Y,Li Q,Qin T,Li S,Jin L,Wu J,Chen K,Deng H,Rao N,Liu Q,Su F,Jia W,Yao H

更新日期：2017-08-01 00:00:00

abstract：CASE REPORT:This case study reports on a patient who relapsed with thymoma (mixed type) nine years after tumor resection. After four courses of rescue chemotherapy (docetaxel and cisplatinum), the patient was further diagnosed with pure red cell aplasia. It was noticed that cyclosporin A (CsA), which was administered t...

journal_title：Anticancer research

authors： Li P,Du F,Gong Z,Hu B,Chi C,Chu H,Chen J

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/AIM:Although the advent of Helicobacter pylori eradication and global societal changes are widely assumed to impact on gastric cancer (GC)-related mortality, there is remarkable little quantitative and qualitative insight into the nature of its effects. Here, we exploited a nationwide reporting system to inv...

journal_title：Anticancer research

authors： Yin J,Song JN,Bai ZG,Cai J,Zhang J,Zheng Z,Wu HW,Ye PP,Gao X,Zhang ZT

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Renal oncocytomas (ROs), and clear cell (RCC) and urothelial carcinomas (UC), are common renal neoplasms. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of NAD+ synthesis and its expression is increased in several tumors. Nampt concomitantly regulates hydrogen sulfide (H2S)-s...

journal_title：Anticancer research

authors： Shackelford RE,Abdulsattar J,Wei EX,Cotelingam J,Coppola D,Herrera GA

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND/AIM:Recent innovations in the treatment of multiple myeloma have enriched our therapeutic repertoire regarding the treatment of multiple myeloma during the last decades. However, despite today's therapies many multiple myeloma (MM) patients experience relapse of disease and eventually remain incurable. Wnt/β...

journal_title：Anticancer research

authors： Schmeel LC,Schmeel FC,Schmidt-Wolf IGH

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND/AIM:Changes in epidermal growth factor receptor (EGFR) are commonly found in cancer progression, signaling a poor outcome in patients. In the present study, we aimed to investigate whether nimotuzumab could be of benefit for cholangiocarcinoma (CCA) treatment. MATERIALS AND METHODS:The expression of EGFR wa...

journal_title：Anticancer research

authors： Padthaisong S,Thanee M,Techasen A,Namwat N,Yongvanit P,Liwatthakun A,Hankla K,Sangkhamanon S,Loilome W

更新日期：2017-07-01 00:00:00

abstract：:Colorectal cancers with high microsatellite instability (MSI-H) have distinct clinical features in terms of their prognosis, recurrence patterns, and sensitivity to immunotherapeutic agents. We present the case of a woman with a left-sided MSI-H colon cancer who had repeated recurrences concentrated exclusively in the...

journal_title：Anticancer research

authors： Greene C,Nakakura EK,Ko AH

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Antibodies against human epidermal growth factor receptor 2 (HER2) affect metastatic breast cancer cells and cardiac myocytes. Guidelines recommend evaluation of cardiac ejection fraction (EF) every 3 months despite little supporting evidence for this need. We assessed the impact of EF screening on clinical ...

journal_title：Anticancer research

authors： Mescher C,Ding C,Defor T,Konety S,Blaes A

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Histological parameters as well as the status of sentinel lymph node are known to be strong prognostic factors in patients with melanoma. PATIENTS AND METHODS:In this study, we retrospectively analyzed 1,384 patients who were diagnosed with head and neck melanoma between 1976 and 2010 regarding prognostic f...

journal_title：Anticancer research

authors： Uslu U,Schuler G,Breuninger H

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Intronic microRNAs (miRNAs) are considered to be transcribed using their host gene promoter. However, about one third of intronic miRNAs are predicted to have independent promoter elements. MATERIALS AND METHODS:Human breast cancer cells were cultured under normoxia or hypoxia, and expression levels of intr...

journal_title：Anticancer research

authors： Kondo H,Shimono Y,Mukohyama J,Tanaka Y,Shibuya N,Minami H,Kakeji Y,Suzuki A

更新日期：2017-07-01 00:00:00

abstract：:Ovarian cancer is the most lethal malignancy among gynaecological cancers. Although many anticancer agents have been developed for the treatment of ovarian cancer, it continues to have an extremely poor prognosis. Heparin-binding epidermal growth factor-like grown factor (HB-EGF) has been reported to be a rational the...

journal_title：Anticancer research

authors： Miyata K,Yotsumoto F,Fukagawa S,Kiyoshima C,Ouk NS,Urushiyama D,Ito T,Katsuda T,Kurakazu M,Araki R,Sanui A,Miyahara D,Murata M,Shirota K,Yagi H,Takono T,Kato K,Yaegashi N,Akazawa K,Kuroki M,Yasunaga S,Miyamoto S

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin and E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefiti...

journal_title：Anticancer research

authors： Kramer B,Hock C,Schultz JD,Lammert A,Kuhlin B,Birk R,Hörmann K,Aderhold C

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Histone acetyltransferase E1A-binding protein p300 (EP300), tumor protein p53 (TP53) and B-cell lymphoma-2-associated X protein (BAX) contribute to the regulation of the cell cycle and apoptosis, cellular processes that are often impaired in cancer cells. The aim of this study was to determine the expression...

journal_title：Anticancer research

authors： Godlewski J,Krazinski BE,Kowalczyk AE,Kiewisz J,Kiezun J,Kwiatkowski P,Sliwińska-Jewsiewicka A,Wierzbicki PW,Kmieć Z

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND/AIM:The definition of vault (ribonucleoprotein particles) function remains highly complex. Vaults may cooperate with multidrug resistance (MDR) proteins, supporting their role in drug resistance. This topic is the main theme of this publication. MATERIALS AND METHODS:The cell viability was determined by an ...

journal_title：Anticancer research

authors： Wojtowicz K,Januchowski R,Nowicki M,Zabel M

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND/AIM:Detection of circulating tumor cells in the perioperative period predicts poor prognosis in patients with colorectal cancer. There is only one Food and Drug Administration-approved method for such detection, CellSearch, for which results have been inconsistent. A new immunological method, CytoTrack, has ...

journal_title：Anticancer research

authors： Gogenur M,Hillig T,Gogenur I

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND/AIM:Reportedly, hypertension tends to be associated with response to bevacizumab therapy, because bevacizumab suppresses vascular nitric oxide production. In this study we examined the predictive value of nitric oxide in bevacizumab-treated non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:F...

journal_title：Anticancer research

authors： Muto S,Takagi H,Owada Y,Inoue T,Watanabe Y,Yamaura T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2017-06-01 00:00:00

abstract：AIM:The purpose of this study was to assess the impairment of the submandibular gland, in terms of changes in volume by computed tomography (CT) and CT value, which was the mean pixel value at a region of interest, in a group of patients with head and neck cancer treated with radiation therapy (RT). PATIENTS AND METHO...

journal_title：Anticancer research

authors： Uchiyama Y,Kreiborg S,Murakami S,Tsujimoto T,Sumida I

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the usefulness of reverse transcription-polymerase chain reaction (RT-PCR) for detecting anaplastic lymphoma kinase (ALK) translocations using cytology samples from lung cancer patients. MATERIALS AND METHODS:We analyzed ALK translocations by RT-PCR in cytology samples from lung cancer pati...

journal_title：Anticancer research

authors： Nakamichi S,Seike M,Miyanaga A,Chiba M,Matsuda K,Kobayashi K,Takahashi A,Takeuchi S,Minegishi Y,Kubota K,Gemma A

更新日期：2017-06-01 00:00:00

abstract：:The attempts to identify, isolate and characterize cancer stem cell populations are mostly dependent on cell-surface markers. In breast cancer, several putative breast cancer stem cell (BCSC) markers have already been reported, but the agreement on their phenotypic characterization is still absent. In fact, it became ...

journal_title：Anticancer research

authors： DA Cruz Paula A,Lopes C

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIM:SLC9A9 plays an oncogenic role in esophageal squamous carcinoma and glioblastoma. Herein, we showed an oncogenic function of SLC9A9 in colorectal cancer (CRC). MATERIALS AND METHODS:We examined SLC9A9 expression in CRC specimens by immunohistochemistry. In CRC tissues, the relationship between SLC9A9 ex...

journal_title：Anticancer research

authors： Ueda M,Iguchi T,Masuda T,Komatsu H,Nambara S,Sakimura S,Hirata H,Uchi R,Eguchi H,Ito S,Sugimachi K,Mizushima T,Doki Y,Mori M,Mimori K

更新日期：2017-05-01 00:00:00